Opportunità di Lavoro

BIOINFORMATICIAN POSITION
AT FONDAZIONE IRCCS ISTITUTO NAZIONALE TUMORI, MILAN, ITALY

A bioinformatician position is available at the Molecular Immunology Unit, headed by Dr. Mario P. Colombo, at the Fondazione IRCCS Istituto Nazionale Tumori, Milan, a leading Center in basic and translational Cancer Research.

The interest of our lab is to understand the interplay between tumor cells, extracellular matrix proteins and immune and non-immune stroma in shaping tumor plasticity, resistance to therapies, and local and systemic immunity. Mouse models of solid (osteosarcoma, breast, prostate) and hematologic tumors as well as human malignancies are investigated. The candidate will collaborate to the Unit research projects for the management and the analysis of genomic data (gene expression profiles, bulk and single cell RNA sequencing data, digital spatial profiling) that will be produced in the different areas.

We are looking for a candidate with the following characteristics:

• A degree in bioinformatics. Degrees in computer science and biology with experience in bioinformatics will be considered as well;
• Good knowledge of Linux environment;
• Good knowledge of scripting and programing languages (for instance R, python);
• Knowledge of management of gene expression data, bulk and single cell RNA sequencing data and, preferably, digital spatial profiling data;
• Knowledge of computational methods for interpreting biological genomic data (such as GSEA, KEGG pathways, GO terms,CIBERSORT).

The candidate should also have a good level of English, good communication skills and a team-oriented working attitude.
The position will be initially for one year, renewable up to five. Salaries will be commensurate to experience.

How to apply
Please send your application including:
• Detailed CV
• Motivation letter
• Name and contacts of two referees

to claudia.chiodoni@istitutotumori.mi.it ; elena.jachetti@istitutotumori.mi.it
Cc mariopaolo.colombo@istitutotumori.mi.it

Postdoctoral Researcher in Tumor Immunology
Location: Istituto Oncologico Veneto IOV-IRCCS, Padova

Finacial Support: Ministry of Health, PNRR-MAD-2022-12375871
Salary: 25k € per year, gross salary
Hours: Full time
Contract Type: 2 year-fellowship
PI: Prof. Vincenzo Bronte

Job Description:

We are seeking a highly motivated postdoc for the immunoprofiling of pancreatic tumors, melanoma and soft-tissue sarcoma and the generation of humanized mouse models using patient-derived samples. This postdoc position will involve conducting experiments, analysing data, writing manuscripts, applying for junior grant calls, actively participating in national and international collaborations as well as helping running the lab. Collaboration and working on multiple projects are highly encouraged.

Specific requirements:

• Required: recent PhD in immunology, oncology or related biomedical disciplines; lab experience in cell culture, multicolour flow cytometry, immunofluorescence or immunohistochemistry; strong teamwork, communication and presentation skills; fluent spoken and written English.

• Desirable:experience with in vivo mouse models; molecular biology; bioinformatics competencies.

Research will be conducted at the Istituto Oncologico Veneto IOV-IRCCS in Padova, a comprehensive cancer center in Italy closely connected with the Department of Surgery, Oncology and Gastroenterology Sciences of the University of Padova, placed in a highly collaborative research environment hosting both preclinical and clinical research.
The laboratories are equipped with state-of-the-art instruments and host scientists with complementary expertise in all areas of cancer biology. Prof. Bronte laboratory is interested in understanding the role of the tumor microenvironment, with a focus on myeloid cells, in the resistance to immunotherapy with the aim of finding new targets that can help boost the efficacy of immunological treatments in resistant patients or hard-to-treat tumors.

For more information and to apply, send a motivation letter, CV with publications and contacts for references to:

vincenzo.gigli@iov.veneto.it
beatrice.agostini@iov.veneto.it

OPEN RESEARCH POSITION
We are looking for an outstanding and highly motivated Scientist to work on the AIRC-funded research project (from April/May 2023) at Istituto Nazionale di Genetica Molecolare (INGM, Milano).

Title of the project: “Targeting IL-10 producing regulatory T-cells in cancer”

PI: Prof. Jens Geginat

INGM is a research Institute with focus on human Immunology and molecular genetics. It is located inside Policlinico Hospital in Milan in the city center of Milan. The environment is stimulating and also offers the possibility to collaborate with clinicians, scientist from other fields and bioinformatics (www.ingm.org). Prof Geginat is the head of the autoimmunity lab in which the attention is focused on cancer immunology and autoimmune disease (www.ingm.org/en/geginat_lab_eng/).

We looking for a curious, hard-working and passionate Scientist, ideally Post-doc, able to work in a team and also to reach goals by him/herself. The ideal candidate should have experience in lymphocyte and/or cell culture, flow cytometry and molecular biology techniques.

Type of contract: “borsa di studio” (renewable)

Salary range: depending on expertise, based on INGM levels for age and expertise.

References:
Alfen et al., J Allergy Clin Immunol 2018,
Gruarin et al., Eur J Immunol 2019
Bonnal, Nature Immunology, 2021,
Geginat et al., EOMESODERMIN-expressingtype1regulatory(EOMES+Tr1)-likeT-cells: basic biology and role in immune-mediated disease, Eur J Immunol 2023 AOP

Please send your CV to:
 Jens Geginat
geginat@ingm.org