Opportunità di Lavoro

Network Italiano per la Bioterapia dei Tumori

Nibit

One post-doctoral position
sponsored by the Italian Association for Cancer Research (AIRC)

One post-doctoral position, sponsored by the Italian Association for Cancer Research (AIRC), is immediately available in the Cellular Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, at the San Raffaele Scientific Institute, Milan, Italy.

The position is offered to investigate the molecular basis of the interactions between the microbiota and the immune system driving multiple myeloma aggressiveness. The interested candidate can check our recent publications in this area to get more insights on the project:

• Bellone M, et al. Microbiol Mol Biol Rev 2020 (doi: 10.1128/MMBR.00064-19)
• Calcinotto A, Brevi A, et al. Nat Commun 2018 (doi: 10.1038/s41467-018-07305-8)
• Calcinotto A, et al., OncoImmunology 2015 (PMID: 26155424)

The successful applicant will participate in a work team that combines high-dimensional multicolor flow cytometry, metagenomics, and genetically engineered mouse models to unveil immunological changes across the gut-bone marrow networks in both humans and preclinical models of multiple myeloma.

Ambitious, and self-motivated ideal candidates for the position with relevant education or experience in immunology are invited to apply, though preference will be given to candidates with experience in flow cytometry. Demonstration of excellent teamwork and collaborative skills will be highly desirable. Please send your curriculum vitae, a brief description of research interests and career goals, and contact information for two references to Dr. Matteo Bellone, via email at: Bellone.matteo@hsr.it

The San Raffaele Scientific Institute is a private organization that includes a research hospital recognized by the Italian Ministry of Health, a research institute and the associated Vita-Salute San Raffaele University. Integrated clinical, research and training activities are conducted with > 1,300 beds, around 1,600 basic, clinical and translational scientists, and almost 3000 students. A common campus hosts all teaching, basic, translational and clinical research activities in a large infrastructural compound. Hence, the San Raffaele offers the opportunity to work in a unique environment where basic, translational and clinical research Units, hospital Departments and teaching activities effectively interact on a daily basis. Mission of the San Raffaele Scientific Institute is to advance the knowledge on human diseases, and to identify novel therapies through basic and translational research. More information can be found at:

https://research.hsr.it/en/divisions/immunology-transplantation-and-infectious-diseases/cellularimmunology/matteo-bellone.html



RESEARCH POSITION
INGM - Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”

We are looking for an outstanding and highly motivated Scientist to work on the AIRC-funded research project (from February 2021):
Targeting IL-10 producing regulatory T-cells in cancer


The ideal successful candidate should have experience with mouse cancer models, lymphocyte culture (both human and murine), flow cytometry and molecular biology techniques. The ideal candidate also should be available to work part of the time in Italy (Milan) and in Bellinzona (Switzerland).

References:
Häringer et al., J Exp Med 2009
Geginat et al., Cyt Growth Fact Rev 2016
Alfen et al., J Allergy Clin Immunol 2018
J Geginat (Editorial), Semin Immunol 2019
Gruarin et al., Eur J Immunol 2019

Please send your CV to Jens Geginat geginat@ingm.org - https://ingm.org/en/geginat_lab_eng


ISTITUTO NAZIONALE GENETICA MOLECOLARE “Romeo ed Enrica Invernizzi”
Via Francesco Sforza, 35 – 20122 Milano, Italia
Tel. +39 02 0066 0211– Fax +39 02 0066 0216 – E-mail: segreteria@ingm.org
Codice Fiscale 04175700964


POSITION AVAILABLE
Research Position at San Raffaele Scientific Institute

A research position is immediately available in the laboratory of Dr. Maria Pia Protti at the Tumor Immunology Unit, Division of Immunology, San Raffaele Scientific Institute of Milan.
The major interest in the laboratory is the study of the tumor microenvironment, and in particular of the immune cell infiltrates with anti- versus pro-tumor functions with special emphasis on the role of T helper (Th) cells.
In the last years we focused on pancreatic ductal adenocarcinoma and we identified a tumorpromoting function for tumor infiltrating Th2 cells that depends on a complex cross-talk between tumor cells, cancer associated fibroblasts and immune cells, within the tumor microenvironment and tumor draining lymph nodes, among which monocytes, tumor associated macrophages, dendritic cells, T cells and basophils (De Monte L et al., J Exp Med 2011; 208:469; De Monte L et al., Cancer Res 76:1792). Cytokines and soluble factors key to the development of Th2 inflammation were also identified, and specifically tumor-derived IL- 1 and cancer associated fibroblast-derived thymic stromal lymphopoietin (TSLP) (Brunetto E, De Monte L et al., J Immunother Cancer 2019;7:45). Targeting of these molecules might impact on the immunosuppressive tumor microenvironment by repolarizing the immune contexture towards anti-tumor Th1 inflammation.
The candidate will be involved in the study of mechanisms of immunosuppression in the pancreatic cancer microenvironment, and of development of therapeutic strategies targeting molecules/cytokines of interest. These studies are conducted in the framework of an international EURONANOMED program testing in vitro and in vivo targeting strategies based on the delivery of therapeutics by nanoparticles. Specifically, the efficacy of blocking IL-1 availability in the tumor microenvironment using the IL-1R antagonist molecule incorporated in nanoparticles will be first tested.
We are looking for a highly motivated candidate (either a junior or post-doctoral fellow) with strong interest in immunology, and experience in cellular immunology and basic molecular biology. Experience in fluorescence and confocal microscopy would be considered a plus.
Interested candidates should send their CVs, a brief statement of research and career interest, and at least one contact information for references to: protti.mariapia@hsr.it



Senior Scientist
The Chair for Functional Immune Cell Modulation at RCI, Prof. Luca Gattinoni is recruiting a Senior Scientist (all gender), reference number LG-2019-5b

with proved experience in the field of human T cell immunobiology and T cellengineering. The position is initially limited to three years with the possibility to be continued and is remunerated on the TV-L salary scale (TV-L EG 14)

The RCI - Regensburg Center for Interventional Immunology (foundation under public law) is a novel biomedical research center focusing on translational immunology in the fields of cancer immunotherapy, transplant rejection and autoimmunity. The objective of the RCI is to develop effective immune therapeutic strategies in these areas.

The senior scientist will be responsible for the development of clinical-grade protocols for the manufacturing of gene-engineered T cells that will be employed in Phase 1/2 clinical studies at the University Hospital Regensburg. Projects derive from recent basic research and translational pre-clinical studies conducted at the RCI and primarily within the Department of Functional Immune Cell Modulation. Gene manipulations encompass the modulation of transcription factors, microRNAs and metabolic checkpoints coupled with CAR and TCR platforms to functionally improve the antitumor efficacy of generedirected T cells.

Responsibilities include, but are not limited to:
• Perform all tasks associated with the manufacturing of clinical-grade cell products including the development of standard operating procedures (SOPs), batch records and other GMP documentation.
• Design and conduct clinical assays required to support assessment of T cell therapies.
• Successfully troubleshoot processing and equipment issues.

The ideal candidate possesses:
• PhD in Molecular Biology, Cell Biology, Immunology or a relevant discipline and 5 or more years of cGMP experience in a T cell manufacturing and biotechnology environment.
• Extensive experience in isolating, culturing human T cells.
• Extensive experience with virus-based and nonviral gene delivery platforms.
• Experience with automated processing equipment.
• Strong knowledge of cGMP regulations and experience in writing SOPs and documentation associated with clinical-grade cell manufacturing.
• Excellent communications skills, both oral and written in English. •Strong analytical, organizational and time management skills.

The RCI follows the goal of professional equality for all genders and therefore strongly encourages qualified women to apply. In addition, the RCI supports work-family balance.

The RCI is an equal opportunity employer and candidates with disabilities will be given preference, provided they are equally qualified.

If we have awakened your interest and you are open to new professional challenges, we would be delighted to receive an informative application from you.


Please send your full application including a statement of interest, curriculum vitae, certificates, expected availability date, a list of publications and 2-3 references by e-mail to Prof. Dr. Philipp Beckhove (bewerbungen.rci@ukr.de). Application deadline is June 30, 2020.

RCI – Regensburger Centrum für Interventionelle Immunologie
c/o Universitätsklinikum Regensburg
Franz-Josef-Strauss-Allee 11
93053 Regensburg
Germany .

For more information contact : Prof. Luca Gattinoni (e-mail: luca.gattinoni@ukr.de phone: +49 941 944 38132)
www.rcii.de


IBAN: IT18R0333201400000000961533